This is unpublished

Antonio
Bedalov
M.D.
Ph.D.

he, him, his
Physician & Research Faculty
Pinned
Academic
Professor, Clinical Research Division, Fred Hutchinson Cancer Research Center
Professor, Division of Medical Oncology, University of Washington
Adjunct Associate Professor, Biochemistry, UW
Sites of Practice
Seattle Cancer Care Alliance

 Photo: Fred Hutch

Education, Training, Board Certifications 

  • M.D., University of Zagreb, Croatia 
  • Ph.D., University of Zagreb, Croatia
  • Residency, Baylor College of Medicine
  • Fellowship, UW
  • Medical Oncology, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine 

Clinical Expertise 

  • Hematopoietic stem cell transplantation
  • Gene therapy

Affiliations

 

Publications   

Research and/or clinical interests 

Dr. Antonio Bedalov studies chromatin, the material that makes up the chromosomes of humans and other eukaryotes. He is learning how chromatin modifications influence important biological events within the cell’s nucleus and, in turn, how they affect development, aging and cancer formation. He also applies this knowledge to lay the groundwork for potential new therapies to treat cancer and other diseases. He has three main research areas. First, he studies how cells regulate the transcription and replication of repetitive DNA sequences. He also studies what happens when these processes break down. Second, Dr. Bedalov is developing potential cancer drugs called sirtuin inhibitors that affect a cell process for regulating gene expression. Dr. Bedalov and collaborator Dr. Julian Simon identified the first sirtuin inhibitors, including one with potent cancer-killing abilities in lab studies. Third, Dr. Bedalov studies X-chromosome inactivation, in which the cells of females silence one of their two X chromosomes. He is interested in manipulating this process as a therapy for Rett syndrome, a genetic disorder that results from a broken gene on one X chromosome.