This is unpublished

Bruce E.
Clurman
M.D.
Ph.D.

he, him, his
Physician & Research Faculty
Pinned
Academic
Executive Vice President and Deputy Director, Fred Hutchinson Cancer Research Center
Professor, Clinical Research Division, Fred Hutch
Professor, Human Biology Division, Fred Hutch
Rosput Reynolds Endowed Chair, Fred Hutch
Professor, Division of Medical Oncology, University of Washington
Adjunct Professor, Department of Pathology, UW
Sites of Practice
Seattle Cancer Care Alliance

Photo: Fred Hutch

Education, Training, Board Certifications

  • M.D., Cornell University Medical College 
  • Ph.D., Cornell University 
  • Residency, Brigham and Women’s Hospital 
  • Fellowship in Medical Oncology, UW
  • Medical Oncology, American Board of Internal Medicine
  • Internal Medicine, American Board of Internal Medicine 

Clinical Expertise  

  • Cell cycles
  • Molecular pathways

Affiliations

Publications

Research and/or clinical interests 

Dr. Bruce Clurman studies the cell cycle, the molecular pathways that drive cells to multiply. This work includes understanding how protein destruction by the ubiquitin–proteasome system controls the cell cycle in normal and cancer cells. His ultimate goal is to understand how these fundamental regulatory pathways shape cancer development and progression, and use this understanding to design new cancer therapies that target these pathways. For example, his group is developing a treatment strategy to capitalize on mutations in key growth-accelerating genes called CDKs. This strategy would push cancer cells toward an unsustainable level of DNA damage without killing healthy cells. Dr. Clurman’s team also is studying how mutations in the gene for Fbw7, a component of the system that regulates destruction of a network of tumor-driving proteins, can cause cancer. The team is designing a drug to restore the function of the mutant Fbw7 in cancers and thus rein in tumor growth.