This is unpublished

Amanda
Paulovich
M.D.
Ph.D.

she, her, hers
Physician & Research Faculty
Pinned
Academic
Professor, Clinical Research Division, Fred Hutchinson Cancer Research Center
Aven Foundation Endowed Chair, Fred Hutch
Professor, Division of Medical Oncology, University of Washington
Director, CLIA Targeted Proteomic Laboratory, Fred Hutch
Director, Clinical Research Proteomics Platform, Brotman Baty Institute

Photo: Fred Hutch

Education, Training, Board Certifications 

  • M.D., University of Washington
  • Ph.D., University of Washington
  • Residency, Massachusetts General Hospital
  • Fellowship in Medical Oncology, Dana Farber Cancer Institute
  • Fellowship in Computational Biology, MIT-Whitehead Center for Genomic Research
  • Internal Medicine, American Board of Internal Medicine

Clinical Expertise  

  • Proteomics
  • Genetics
  • Adult Oncology

Affiliations 

Publications

Research and/or clinical interests 

Dr. Amanda Paulovich is a leader in proteomics, the study of proteins — the cell’s workhorse molecules. Due to a lack of tools, proteomics has lagged behind the study of genes, which provide the blueprints for proteins. And just as a blueprint cannot tell you everything about a finished house, our genetic blueprint only reveals part of the biological picture. By developing powerful protein-measuring tools, Dr. Paulovich helps to fill in this picture and open the door to treatments tailored to individual cancer patients.

Her team has spearheaded the development of assays that use a technique called multiple reaction monitoring mass spectrometry, or MRM-MS, to detect and precisely measure the amount of a particular protein. This technology will help researchers combine detailed information about proteins with genetic data to learn, for instance, which genetic mutations drive a cancer’s development and suggest and characterize new therapeutic targets.